<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:bd611c33-4cdc-4512-84e5-96a882112e2f,g:47f932ad-0af4-44e4-ab92-827c2806dc27-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:wynn="http://www.wynnresorts.com/20220630" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2020-01-21" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.wynnresorts.com/20220630">
  <xs:import namespace="http://fasb.org/srt/2021-01-31" schemaLocation="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2021-01-31" schemaLocation="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd"/>
  <xs:import namespace="http://www.w3.org/1999/xlink" schemaLocation="http://www.xbrl.org/2003/xlink-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2020-01-21" schemaLocation="https://www.xbrl.org/dtr/type/2020-01-21/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/country/2021" schemaLocation="https://xbrl.sec.gov/country/2021/country-2021.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2021" schemaLocation="https://xbrl.sec.gov/dei/2021/dei-2021.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="wynn-20220630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="wynn-20220630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="wynn-20220630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="wynn-20220630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="Cover" roleURI="http://www.wynnresorts.com/role/Cover">
        <link:definition>0001001 - Document - Cover</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheets" roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheets">
        <link:definition>1001002 - Statement - Condensed Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheetsParenthetical" roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedBalanceSheetsParenthetical">
        <link:definition>1002003 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofOperationsunaudited" roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofOperationsunaudited">
        <link:definition>1003004 - Statement - Condensed Consolidated Statements of Operations (unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofComprehensiveIncomeLossunaudited" roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeLossunaudited">
        <link:definition>1004005 - Statement - Condensed Consolidated Statements of Comprehensive Income (Loss) (unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementofStockholdersDeficitunaudited" roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementofStockholdersDeficitunaudited">
        <link:definition>1005006 - Statement - Condensed Consolidated Statement of Stockholders' Deficit (unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementofStockholdersDeficitunauditedParenthetical" roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementofStockholdersDeficitunauditedParenthetical">
        <link:definition>1006007 - Statement - Condensed Consolidated Statement of Stockholders' Deficit (unaudited) (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofCashFlowsunaudited" roleURI="http://www.wynnresorts.com/role/CondensedConsolidatedStatementsofCashFlowsunaudited">
        <link:definition>1007008 - Statement - Condensed Consolidated Statements of Cash Flows (unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Organization" roleURI="http://www.wynnresorts.com/role/Organization">
        <link:definition>2101101 - Disclosure - Organization</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OrganizationDetails" roleURI="http://www.wynnresorts.com/role/OrganizationDetails">
        <link:definition>2402401 - Disclosure - Organization (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSignificantAccountingPolicies" roleURI="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPolicies">
        <link:definition>2103102 - Disclosure - Basis of Presentation and Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSignificantAccountingPoliciesPolicies" roleURI="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesPolicies">
        <link:definition>2204201 - Disclosure - Basis of Presentation and Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSignificantAccountingPoliciesAdditionalInformationDetails" roleURI="http://www.wynnresorts.com/role/BasisofPresentationandSignificantAccountingPoliciesAdditionalInformationDetails">
        <link:definition>2405402 - Disclosure - Basis of Presentation and Significant Accounting Policies - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CashCashEquivalentsandRestrictedCash" roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCash">
        <link:definition>2106103 - Disclosure - Cash, Cash Equivalents and Restricted Cash</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CashCashEquivalentsandRestrictedCashTables" roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashTables">
        <link:definition>2307301 - Disclosure - Cash, Cash Equivalents and Restricted Cash (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CashCashEquivalentsandRestrictedCashDetails" roleURI="http://www.wynnresorts.com/role/CashCashEquivalentsandRestrictedCashDetails">
        <link:definition>2408403 - Disclosure - Cash, Cash Equivalents and Restricted Cash (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Receivablesnet" roleURI="http://www.wynnresorts.com/role/Receivablesnet">
        <link:definition>2109104 - Disclosure - Receivables, net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ReceivablesnetTables" roleURI="http://www.wynnresorts.com/role/ReceivablesnetTables">
        <link:definition>2310302 - Disclosure - Receivables, net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ReceivablesnetDetails" roleURI="http://www.wynnresorts.com/role/ReceivablesnetDetails">
        <link:definition>2411404 - Disclosure - Receivables, net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ReceivablesnetScheduleofMovementinAllowanceforCreditLossesRecognizedforReceivablesDetails" roleURI="http://www.wynnresorts.com/role/ReceivablesnetScheduleofMovementinAllowanceforCreditLossesRecognizedforReceivablesDetails">
        <link:definition>2412405 - Disclosure - Receivables, net - Schedule of Movement in Allowance for Credit Losses Recognized for Receivables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyandEquipmentnet" roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnet">
        <link:definition>2113105 - Disclosure - Property and Equipment, net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyandEquipmentnetTables" roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetTables">
        <link:definition>2314303 - Disclosure - Property and Equipment, net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyandEquipmentnetScheduleofPropertyandEquipmentNetDetail" roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetScheduleofPropertyandEquipmentNetDetail">
        <link:definition>2415406 - Disclosure - Property and Equipment, net - Schedule of Property and Equipment, Net (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyandEquipmentnetNarrativeDetails" roleURI="http://www.wynnresorts.com/role/PropertyandEquipmentnetNarrativeDetails">
        <link:definition>2416407 - Disclosure - Property and Equipment, net - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssetsnet" roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnet">
        <link:definition>2117106 - Disclosure - Goodwill and Intangible Assets, net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssetsnetTables" roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetTables">
        <link:definition>2318304 - Disclosure - Goodwill and Intangible Assets, net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssetsnetScheduleofIntangibleAssetsNetDetails" roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetScheduleofIntangibleAssetsNetDetails">
        <link:definition>2419408 - Disclosure - Goodwill and Intangible Assets, net - Schedule of Intangible Assets, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssetsnetNarrativeDetails" roleURI="http://www.wynnresorts.com/role/GoodwillandIntangibleAssetsnetNarrativeDetails">
        <link:definition>2420409 - Disclosure - Goodwill and Intangible Assets, net - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebt" roleURI="http://www.wynnresorts.com/role/LongTermDebt">
        <link:definition>2121107 - Disclosure - Long-Term Debt</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebtTables" roleURI="http://www.wynnresorts.com/role/LongTermDebtTables">
        <link:definition>2322305 - Disclosure - Long-Term Debt (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebtSummaryofLongTermDebtDetail" roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtDetail">
        <link:definition>2423410 - Disclosure - Long-Term Debt - Summary of Long-Term Debt (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail" roleURI="http://www.wynnresorts.com/role/LongTermDebtSummaryofLongTermDebtAdditionalInformationDetail">
        <link:definition>2424411 - Disclosure - Long-Term Debt - Summary of Long-Term Debt - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebtAdditionalInformationDetail" roleURI="http://www.wynnresorts.com/role/LongTermDebtAdditionalInformationDetail">
        <link:definition>2425412 - Disclosure - Long-Term Debt - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityDeficit" roleURI="http://www.wynnresorts.com/role/StockholdersEquityDeficit">
        <link:definition>2126108 - Disclosure - Stockholders' Equity (Deficit)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityDeficitDetails" roleURI="http://www.wynnresorts.com/role/StockholdersEquityDeficitDetails">
        <link:definition>2427413 - Disclosure - Stockholders' Equity (Deficit) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurements" roleURI="http://www.wynnresorts.com/role/FairValueMeasurements">
        <link:definition>2128109 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsTables" roleURI="http://www.wynnresorts.com/role/FairValueMeasurementsTables">
        <link:definition>2329306 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsDetails" roleURI="http://www.wynnresorts.com/role/FairValueMeasurementsDetails">
        <link:definition>2430414 - Disclosure - Fair Value Measurements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CustomerContractLiabilities" roleURI="http://www.wynnresorts.com/role/CustomerContractLiabilities">
        <link:definition>2131110 - Disclosure - Customer Contract Liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CustomerContractLiabilitiesTables" roleURI="http://www.wynnresorts.com/role/CustomerContractLiabilitiesTables">
        <link:definition>2332307 - Disclosure - Customer Contract Liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CustomerContractLiabilitiesScheduleofCustomerContractLiabilitiesDetails" roleURI="http://www.wynnresorts.com/role/CustomerContractLiabilitiesScheduleofCustomerContractLiabilitiesDetails">
        <link:definition>2433415 - Disclosure - Customer Contract Liabilities Schedule of Customer Contract Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensation" roleURI="http://www.wynnresorts.com/role/StockBasedCompensation">
        <link:definition>2134111 - Disclosure - Stock-Based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationTables" roleURI="http://www.wynnresorts.com/role/StockBasedCompensationTables">
        <link:definition>2335308 - Disclosure - Stock-Based Compensation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationShareBasedCompensationAllocatedCostsDetail" roleURI="http://www.wynnresorts.com/role/StockBasedCompensationShareBasedCompensationAllocatedCostsDetail">
        <link:definition>2436416 - Disclosure - Stock-Based Compensation - Share Based Compensation Allocated Costs (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxes" roleURI="http://www.wynnresorts.com/role/IncomeTaxes">
        <link:definition>2137112 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesAdditionalInformationDetail" roleURI="http://www.wynnresorts.com/role/IncomeTaxesAdditionalInformationDetail">
        <link:definition>2438417 - Disclosure - Income Taxes - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EarningsPerShare" roleURI="http://www.wynnresorts.com/role/EarningsPerShare">
        <link:definition>2139113 - Disclosure - Earnings Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EarningsPerShareTables" roleURI="http://www.wynnresorts.com/role/EarningsPerShareTables">
        <link:definition>2340309 - Disclosure - Earnings Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EarningsPerShareScheduleofSharesusedinCalculationofEarningsPerShareDetail" roleURI="http://www.wynnresorts.com/role/EarningsPerShareScheduleofSharesusedinCalculationofEarningsPerShareDetail">
        <link:definition>2441418 - Disclosure - Earnings Per Share - Schedule of Shares used in Calculation of Earnings Per Share (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Leases" roleURI="http://www.wynnresorts.com/role/Leases">
        <link:definition>2142114 - Disclosure - Leases</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesTables" roleURI="http://www.wynnresorts.com/role/LeasesTables">
        <link:definition>2343310 - Disclosure - Leases (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesMinimumandContingentOperatingLeaseIncomeDetails" roleURI="http://www.wynnresorts.com/role/LeasesMinimumandContingentOperatingLeaseIncomeDetails">
        <link:definition>2444419 - Disclosure - Leases - Minimum and Contingent Operating Lease Income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedPartyTransactions" roleURI="http://www.wynnresorts.com/role/RelatedPartyTransactions">
        <link:definition>2145115 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedPartyTransactionsDetails" roleURI="http://www.wynnresorts.com/role/RelatedPartyTransactionsDetails">
        <link:definition>2446420 - Disclosure - Related Party Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingencies" roleURI="http://www.wynnresorts.com/role/CommitmentsandContingencies">
        <link:definition>2147116 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RetailJointVenture" roleURI="http://www.wynnresorts.com/role/RetailJointVenture">
        <link:definition>2148117 - Disclosure - Retail Joint Venture</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RetailJointVentureAdditionalinformationDetails" roleURI="http://www.wynnresorts.com/role/RetailJointVentureAdditionalinformationDetails">
        <link:definition>2449421 - Disclosure - Retail Joint Venture - Additional information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentInformation" roleURI="http://www.wynnresorts.com/role/SegmentInformation">
        <link:definition>2150118 - Disclosure - Segment Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentInformationTables" roleURI="http://www.wynnresorts.com/role/SegmentInformationTables">
        <link:definition>2351311 - Disclosure - Segment Information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentInformationSummaryofResultsofOperationsbySegmentDetails" roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofResultsofOperationsbySegmentDetails">
        <link:definition>2452422 - Disclosure - Segment Information - Summary of Results of Operations by Segment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentInformationSummaryofAssetsbySegmentDetails" roleURI="http://www.wynnresorts.com/role/SegmentInformationSummaryofAssetsbySegmentDetails">
        <link:definition>2453423 - Disclosure - Segment Information - Summary of Assets by Segment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="wynn_WaterRightsAndOtherMember" abstract="true" name="WaterRightsAndOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_GamingConcessionExtensionDemandBankGuarantee" abstract="false" name="GamingConcessionExtensionDemandBankGuarantee" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_SeniorRevolvingCreditFacilityDue2024Member" abstract="true" name="SeniorRevolvingCreditFacilityDue2024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember" abstract="true" name="WynnCAPlazaPropertyOwnerLLCAndWynnCAPropertyOwnerLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember" abstract="true" name="FiveandOneHalfPercentSeniorNotesDueMarchOneTwentyTwentyFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_LossesOnExtinguishmentOfDebt" abstract="false" name="LossesOnExtinguishmentOfDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_NumberOfGamingConcessions" abstract="false" name="NumberOfGamingConcessions" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="wynn_HIBORMember" abstract="true" name="HIBORMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_WynnMacauLimitedMember" abstract="true" name="WynnMacauLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_OtherOperatingCostsAndExpensesAbstract" abstract="true" name="OtherOperatingCostsAndExpensesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="wynn_Loyaltyprograms" abstract="false" name="Loyaltyprograms" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember" abstract="true" name="FiveAndFiveOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_WynnResortsFinanceLLCMember" abstract="true" name="WynnResortsFinanceLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_GamingConcessionsTerm" abstract="false" name="GamingConcessionsTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wynn_OtherMacauMember" abstract="true" name="OtherMacauMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_ScheduleOfIntangibleAssetsTable" abstract="true" name="ScheduleOfIntangibleAssetsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="wynn_WynnResortsLtdMember" abstract="true" name="WynnResortsLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_WMCaymanIIRevolverDue2025Member" abstract="true" name="WMCaymanIIRevolverDue2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_RetailLeasesAndOtherMember" abstract="true" name="RetailLeasesAndOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember" abstract="true" name="FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_WynnLasVegasLLCandWynnLasVegasCapitalCorpMember" abstract="true" name="WynnLasVegasLLCandWynnLasVegasCapitalCorpMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_ScheduleofCustomerContractLiabilitiesTableTextBlock" abstract="false" name="ScheduleofCustomerContractLiabilitiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="wynn_Othergamingrelatedliabilities" abstract="false" name="Othergamingrelatedliabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_GamingTaxExpenses" abstract="false" name="GamingTaxExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearsOneThroughEleven" abstract="false" name="FiniteLivedIntangibleAssetExpectedAmortizationYearsOneThroughEleven" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_TotalCustomerContractLiabilities" abstract="false" name="TotalCustomerContractLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_IntangibleAssetsOtherLiabilitiesIncurred" abstract="false" name="IntangibleAssetsOtherLiabilitiesIncurred" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_WynnPalaceMember" abstract="true" name="WynnPalaceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" abstract="true" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="wynn_NetIncomeLossAvailableCommonStockholdersBasicAndDilutedAbstract" abstract="true" name="NetIncomeLossAvailableCommonStockholdersBasicAndDilutedAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="wynn_Changeinothergamingrelatedliabilities" abstract="false" name="Changeinothergamingrelatedliabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_Changeinloyaltyprogramliabilities" abstract="false" name="Changeinloyaltyprogramliabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_AdditionalPaidInCapitalSubsidiaryStockIssuedDuringPeriodValueNewIssues" abstract="false" name="AdditionalPaidInCapitalSubsidiaryStockIssuedDuringPeriodValueNewIssues" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_MacauGamingConcessionMember" abstract="true" name="MacauGamingConcessionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_HIBOROrLIBORMember" abstract="true" name="HIBOROrLIBORMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_PublicStockOfferingMember" abstract="true" name="PublicStockOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_CrownAcquisitionsIncMember" abstract="true" name="CrownAcquisitionsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_WynnPalaceandWynnMacauMember" abstract="true" name="WynnPalaceandWynnMacauMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_AccountsReceivableAllowanceForCreditLossEffectOfExchangeRate" abstract="false" name="AccountsReceivableAllowanceForCreditLossEffectOfExchangeRate" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_GamingConcessionsExtensionTerm" abstract="false" name="GamingConcessionsExtensionTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wynn_April2016RepurchaseProgramMember" abstract="true" name="April2016RepurchaseProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_MassachusettsGamingLicenseMember" abstract="true" name="MassachusettsGamingLicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_DebtInstrumentBasisSpreadOnVariableRateFloor" abstract="false" name="DebtInstrumentBasisSpreadOnVariableRateFloor" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wynn_PaymentsForUseOfIntangibleAssets" abstract="false" name="PaymentsForUseOfIntangibleAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_IncreaseDecreaseInInventoriesPrepaidExpensesAndOtherCurrentAssets" abstract="false" name="IncreaseDecreaseInInventoriesPrepaidExpensesAndOtherCurrentAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_WMCaymanHoldingsLimitedIIMember" abstract="true" name="WMCaymanHoldingsLimitedIIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_Advancedroomdepositsandticketsales" abstract="false" name="Advancedroomdepositsandticketsales" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember" abstract="true" name="FourandSevenOverEightPercentageWynnMacauLimitedSeniorNotesDueOctoberOneTwoThousandTwentyFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_Casinooutstandingchipsandfrontmoneydeposits" abstract="false" name="Casinooutstandingchipsandfrontmoneydeposits" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_EntertainmentRetailAndOtherMember" abstract="true" name="EntertainmentRetailAndOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_GeneralAndAdministrativeMember" abstract="true" name="GeneralAndAdministrativeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_SaleLeasebackTransactionGrossProceeds" abstract="false" name="SaleLeasebackTransactionGrossProceeds" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_SaleLeasebackTransactionMinimumAnnualRentalPayments" abstract="false" name="SaleLeasebackTransactionMinimumAnnualRentalPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_IncreaseDecreaseinoutstandingchipsandfrontmoneydeposits" abstract="false" name="IncreaseDecreaseinoutstandingchipsandfrontmoneydeposits" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" abstract="true" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="wynn_EncoreBostonHarborMember" abstract="true" name="EncoreBostonHarborMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember" abstract="true" name="FiveAndOneOverEightPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_AccountsPayableCurrentAmountRelatedtoPropertyPlantandEquipment" abstract="false" name="AccountsPayableCurrentAmountRelatedtoPropertyPlantandEquipment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_ShareCapitalHeldByManagingDirectorPercentage" abstract="false" name="ShareCapitalHeldByManagingDirectorPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wynn_FiniteLivedIntangibleAssetExpectedAmortizationYearTwelve" abstract="false" name="FiniteLivedIntangibleAssetExpectedAmortizationYearTwelve" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_ProceedsFromDivestitureOfInterestInJointVentureFinancingActivities" abstract="false" name="ProceedsFromDivestitureOfInterestInJointVentureFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_Changeintotalcustomercontractliabilities" abstract="false" name="Changeintotalcustomercontractliabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_GamingTaxesPolicyPolicyTextBlock" abstract="false" name="GamingTaxesPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="wynn_GamingTaxesPayableCurrent" abstract="false" name="GamingTaxesPayableCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_RoomsMember" abstract="true" name="RoomsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_SaleLeasebackTransactionTerm" abstract="false" name="SaleLeasebackTransactionTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="wynn_WynnInteractiveLtdMember" abstract="true" name="WynnInteractiveLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_GamingConcessionMinimumCapitalRequirement" abstract="false" name="GamingConcessionMinimumCapitalRequirement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember" abstract="true" name="FourAndOneOverFourPercentageWynnLasVegasSeniorNotesDueMayThirtyTwoThousandTwentyThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_FiveAndOneOverEightPercentageSeniorNotesDue2029Member" abstract="true" name="FiveAndOneOverEightPercentageSeniorNotesDue2029Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_Changeinadvancedroomdepositsandticketsales" abstract="false" name="Changeinadvancedroomdepositsandticketsales" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_WynnLasVegasMember" abstract="true" name="WynnLasVegasMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_WynnMacauMember" abstract="true" name="WynnMacauMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_WRFSeniorSecuredCreditFacilitiesMember" abstract="true" name="WRFSeniorSecuredCreditFacilitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_BetbullTransactionMember" abstract="true" name="BetbullTransactionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member" abstract="true" name="FiveAndOneOverFourPercentageSeniorNotesDueMay152027Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_CorporateExpensesAndOther" abstract="false" name="CorporateExpensesAndOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_RevenueRecognitionTextBlock" abstract="false" name="RevenueRecognitionTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="wynn_ScheduleOfIntangibleAssetsLineItems" abstract="true" name="ScheduleOfIntangibleAssetsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="wynn_FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember" abstract="true" name="FiveAndOneOverTwoPercentageWynnMacauLimitedSeniorNotesDueTwoThousandTwentySixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member" abstract="true" name="SevenAndThreeOverFourPercentageWRFSeniorNotesDue2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_RetailTermLoanAgreementMember" abstract="true" name="RetailTermLoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables" abstract="false" name="AccountsReceivableAllowanceForCreditLossPercentOfGrossCasinoReceivables" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="wynn_SaleOfStockConsiderationReceivedOnTransactionNetAmortizationOfDiscountAndPremium" abstract="false" name="SaleOfStockConsiderationReceivedOnTransactionNetAmortizationOfDiscountAndPremium" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_RetailJointVentureMember" abstract="true" name="RetailJointVentureMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_PropertyChargesandOther" abstract="false" name="PropertyChargesandOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_SeniorTermLoanFacilityDue2024Member" abstract="true" name="SeniorTermLoanFacilityDue2024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_AdjustedPropertyEbitda" abstract="false" name="AdjustedPropertyEbitda" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_ProjectAbandonmentCosts" abstract="false" name="ProjectAbandonmentCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_PaymentsForDividendTaxAgreement" abstract="false" name="PaymentsForDividendTaxAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_MacauOperationsMember" abstract="true" name="MacauOperationsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="wynn_ProceedsFromIssuanceOfSubsidiaryCommonStock" abstract="false" name="ProceedsFromIssuanceOfSubsidiaryCommonStock" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="wynn_WeightedAverageNumberOfSharesOutstandingBasicAndDilutedAbstract" abstract="true" name="WeightedAverageNumberOfSharesOutstandingBasicAndDilutedAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
</xs:schema>
